About the Center for Medical Polymers and Biomaterials
The research team headed by Prof. Ramaz Katsarava was organized in 1977 as a research group of Bioactive Polymers at the Department of Biophysics of I. Beritashvili Institute of Physiology of the Georgian Academy of Sciences. In 1986 a new Institute of Biophysics and Molecular Biology was separated from the Institute of Physiology and the group was transformed into Laboratory of Bioactive Polymers. Since 1997 the Katsaravas research team moved to the Georgian Technical University and founded the Research Center for Medical Polymers and Biomaterials.
Activities and Product Descriptions
Our research program is based on a cross disciplinary approach where aspects of engineering, chemistry, and biology are applied to the field of Biomaterial. We are focused on the creation of new highly biocompatible & biodegradable polymers poly(ester amide)s and poly(ester urethane)s entirely composed of naturally occurring and non-toxic building blocks (like naturally occurring amino acids, fatty dicarboxylic acids and diols) through controlled polymer chemistry and engineering. The polymers created a wide reveal range of mechanical properties from hard to elastic film-forming. Their hydrophilicity/hydrophobicity balance and bio-degradation (bio-erosion) rates are varied in a wide range. The polymers created are promising both as absorbable surgical materials and as polymeric drugs for sustained release local drug delivery for the treatment of various diseases.
The biodegradable polymers created displayed a wide range of material properties from film and fiber forming to hydrophilic elastomers and are subjected the hydrolysis (biodegradation) with a high rate [0.1-0.01 mg/(cm2 h)], catalyzed by enzymes (hydrolases) like trypsin???. chymotrypsin, lipase, & esterase. Active forms of the enzymes can be both surface-immobilized and bulkimpregnated in the polymers. Essential ??amino acids releasing after biodegradation of the polymers can be assimilated by living organism through metabolic means promoting omit tissue regeneration.
In bridging polymer science and microbiology, we are designing biocomposite materials containing bacteriophages as bactericidal substances . These biomaterials, prepared as both films and powders are promising as dressings for accelerated healing of infected wounds and cavities like Tropic and Diabetic Ulcers, Bedsores, Osteomyelitis, for treatment of dental diseases like Gingivitis and Paradontitis, as well as, for the application in Ophthalmology and Gynecology. Some clinical results are described in the recent publication [2,3].
We have also developed a unique bioabsorbable, elastomeric functional poly(ester amide) for local drug delivery . This polymer has shown great promise in the field of cardiovascular medicine as a vector for sustained, controlled release of drugs for the treatment of in stent restenosis . Currently the vascular stents coated by the same co-PEA are under first phase clinical trials.
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